Children and adolescents at risk for psychosis: transition and baseline characteristics

Poster B112, Tuesday, October 9, 11:30 am - 1:00 pm, Essex Ballroom

Montserrat Dolz1,2,4, Jordina Tor1,2, Laia Portolés1,2, Marta Pardo1,2, Daniel Muñoz-Samons1,2, Marta Rodriguez-Pascual1,2, Xavier Álvarez1,2, Elena De la Serna3,4,5, Daniel Ilzarbe3,4, Olga Puig3,4, Gisela Sugranyes3,4,5, Inmaculada Baeza3,4,5; 1Child and Adolescent Mental Health Research Group. Institut de Recerca Sant joan de Déu., 2Child and Adolescent Psychiatry and Psychology Department. Hospital Sant Joan de Déu of Barcelona. Spain., 3Department of Child and Adolescent Psychiatry and Psychology. Hospital Clinic Universitari of Barcelona. Spain, 4Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain, 5Institut Clinic of Neurosciences, CERCA-IDIBAPS. Hospital Clínic Universitari of Barcelona, Department of Psychiatry and Psychobiology, Health Sciences Division, University of Barcelona. Spain.

Objective: The aim of this study is to determinate transition rates and baseline differences between adolescents at clinical high risk (CHR) who convert (CHR-P) or who did not convert (CHR-NP) to a psychotic disorder. Method: Multi-site, naturalistic and longitudinal sample of CHR help-seeking were recruited from two hospitals from Barcelona. Inclusion criteria were having one of the three CHR criteria (positive attenuated psychotic symptoms, brief limited psychotic symptoms or genetic risk syndrome) assessed by Structured Interview of Prodromal Syndromes (SIPS). Socio-demographical, clinical and neuropsychological variables at baseline 6, 12 and 18 months were registered. Pair-wise differences were performed to show differences at baseline between CHR-P and CHR-NP. Results: A total of 70 patients were clinically followed. Mean age at baseline was 15.29 ±1.6, and 45 were females (64.2%). At 18 months follow-up, 23 (32.8%) patients developed a psychotic disorder. No differences in socio-demographic characteristics at baseline were founded between CHR-P and CHR-NP. In terms of clinical symptoms and functioning, CHR-P show lower scores in the Global Assessment of Functioning at baseline (p=0.034), a trend tendency of higher presence of anxiety diagnosis at baseline (p=0.057) and a trend tendency of higher scores of the sub-item of grandiosity assessed by SIPS (p=0.079) than CHR-NP. Conclusions: 32.8% of children and adolescents at risk developed a psychotic disorder during 18 months of follow-up, showing transition rates higher than those presented in children and adolescent samples in Europe (Tor et al., 2017), but similar to those showed in adult samples (Schultze-Lutter et al., 2015).

Topic Area: Ultra High Risk / Prodromal Research

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