Real World Effectiveness of Antipsychotic Drugs in Patients with Schizophrenia: A 10-years retrospective study

Poster A107, Monday, October 8, 11:30 am - 1:00 pm, Essex Ballroom

Tae Young Lee1, Minah Kim1, Junhee Lee1, Jun Soo Kwon1,2; 1Seoul National University College of Medicine, 2Seoul National University College of Natural Sciences

Discontinuation of antipsychotics in patients with schizophrenia has increasing attention as a representative treatment effectiveness of the medication. The objective of present study is to determine which antipsychotic medication is highly effective in a real-world clinical setting considering adjuvant pharmacotherapy over a 10-year follow-up period. A total of 2300 patients with schizophrenia were recruited at the Seoul National University Hospital, and participants received amisulpride, aripiprazole, clozapine, haloperidol, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone for up to 10-years. Time-to-discontinuation of antipsychotic medications was analyzed using Kaplan-Meier survival analyses. Group differences were compared using log-rank tests. The most frequently used drugs were Risperidone, Aripiprazole, Olanzapine in the antipsychotic drug, Valproate, Lamotrigine, Topiramate in the anticonvulsant agents, Escitalopram, Sertraline, Milnacipran in antidepressants, Lorazepam, Clonazepam, Zolpidem in anxiolytics or sedatives, Propranolol, Benztropine, Trihexyphenidyl in antiparkinson drugs. About half of the patients discontinued taking antipsychotics before 1.5 years. Clozapine showed significantly longer time to discontinuations compared to other antipsychotic drugs. Aripiprazole also showed a lower incidence of discontinuation except for Clozapine and Olanzapine. Clozapine was found to be the most effective antipsychotics in terms of time to discontinuations. Aripiprazole is the most highly recommeded 1st line antipsychotics.

Topic Area: Psychopharmacology

Back to Poster Schedule