Personality traits of prodromal psychosis

Poster B102, Tuesday, October 9, 11:30 am - 1:00 pm, Essex Ballroom

Shimako Nishiyama1, Yuko Higchi1, Yuko Komori1, Tsutomu Takahashi1, Michio Suzuki1; 1University of Toyama Graduate School of Medicine and Pharmaceutical Sciences

Objective: The traits of personality associated with the development of psychosis remains unclear. Therefore we aimed to explore personality traits at prodromal psychosis. Methods: Participants were 65 ultra high risk for psychosis (UHR) individuals, 44 patients with first episode of schizophrenia (FES), and 60 healthy controls. Eight UHR individuals transitioned to psychosis (UHR-T), while 27 did not during one-year follow up (UHR-NT). The Minnesota Multiphasic Personality Inventory (MMPI) was administered to all subjects at baseline. Results: The UHR and the FES groups demonstrated significantly higher scores on the eight scales (Scale 1, Hypochondriasis; Scale 2, Depression; Scale 3, Hysteria; Scale 4, Psychopathic Deviate; Scale 6, Paranoia; Scale 7, Psychasthenia; Scale 8, Schizophrenia; Scale 0, Social Introversion) as compared with the healthy control group. The UHR group showed significantly lower scores on the Scale 6 and the Scale 8 than the FES group. The UHR-T group showed significantly higher scores on the Scale 6 and the Scale 8 than the UHR-NT, but there was no significant difference between the UHR-T and FES groups. The UHR-T group had significantly higher score compared with the UHR-NT and the FES groups on the Scale 7. Conclusions: The high risk state for psychosis was characterized by more attenuated persecutory ideas, poignancy and bizzare sensory experiences in comparison to the onset of psychosis. On the other hand, the high risk and the first episode of psychosis were similar in severity of depressive state, anxiety, introversion and physical complainants. Furthermore, the subjects with prodromal state, namely who later developed psychosis, already exhibited the comparable psychotic features to and more severe anxiety than the first episode patients at the baseline.

Topic Area: Ultra High Risk / Prodromal Research

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