Glutamate and GABA in UHR

Poster B119, Tuesday, October 9, 11:30 am - 1:00 pm, Essex Ballroom

Christina Wenneberg1,2,4, Birte Yding Glenthøj2,3, Egill Rostrup2,3,4, Louise Birkedal Glenthøj1,2, Kristine Krakauer1,2, Tina Kristensen1,2, Brian Broberg2,3, Merete Nordentoft1; 1Mental Health Centre, Copenhagen, 2Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Centre Glostrup, University of Copenhagen, Denmark, 3Center for Neuropsychiatric Schizophrenia Research, CNSR, 4Functional Imaging Unit, Department of Diagnostics, Glostrup University Hospital, Glostrup Denmark

Background: Disturbances of the neurotransmitters glutamate and GABA have long been suspected to be involved in the pathophysiology of psychosis. These disorders have also found been found in people at UHR, making it a promising area for early detection. Cognitive deficits in schizophrenia are present prior to the onset of psychosis, and may be linked to perturbed glutamate and GABA function. Data suggest that this link is already present in UHR states. Methods: Participants: UHR individuals who meet the CAARMS criteria recruited from Mental Health Services in the Capital Region of Denmark and matching healthy controls. Examinations: 1H-MRS of the ACC and thalamus. Diagnostic and psychopathological tests: CAARMS, SCID, SOFAS, PSP, Cornblatt, SANS, BPRS, MADRS, YMRS, CGI, PAS, SPI-A, AQoL Cognitive tests as part of collaborative studies Results So far 124 UHR individuals and 49 healthy controls have been scanned (April 2018) Preliminary analysis of the baseline data finds no significant difference in glutamate levels (in ACC and thalamus) in UHR patients compared to matched healthy controls. Baseline data remains to be analysed in relation to relevant subgroups of patients e.g. based on clinical outcome. GABA analysis and analysis of follow-up data are also yet to be performed. Data will be ready for the meeting, and will be presented. Discussion: More studies are needed in this field, since results so far have been diverging.

Topic Area: Ultra High Risk / Prodromal Research

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