Isolated hallucination does not predict psychosis: Insight from a longitudinal study in a clinical population at high risk for psychosis

Poster B104, Tuesday, October 9, 11:30 am - 1:00 pm, Essex Ballroom

Yan Wang1, TianHong Zhang, LiHua Xu, YingYing Tang, HuiRu Cui, YanYan Wei, XiaoChen Tang, Qiang Hu, YiKang Zhu, LiJuan Jiang, XiaoHua Liu, JiJun Wang; 1Shanghai Mental Health Center

Perceptual abnormalities (PAs) such as auditory hallucinations are one of the most common symptoms of psychotic patients. However, it remains unclear whether symptoms of sub-clinical PAs also play a key role in predicting psychosis. In an ongoing prospective follow-up study of individuals at a clinical high risk (CHR) of psychosis, we evaluated the potential of first-time experience of PAs and/or thought content disorders (TCDs) to predict psychosis. Conversion to psychosis was the major focus of this follow-up study. A total of 511 CHRs were recruited, of whom 443(86.7%) completed the clinical follow-up of at least 6 months and up to 2 years. CHRs were divided into four groups according to the presence of PAs and/or TCDs. At the follow-up endpoint, 39(19.9%) CHRs in the “TCDs-only” group, 2(8.3%) in the “PAs-only” group,45 (17.0%) in the “TCDs-and-PAs” group, and 1(3.8%) in the “None” group converted to psychosis. Survival analysis revealed a higher conversion rate in CHRs with TCDs compared with those with PAs only. CHRs with isolated PAs had shown a higher level of dysphoric mood at baseline compared with those with TCDs. About 89% TCDs contents were related with their experienced PAs. The isolated PAs are not strongly associated with increased susceptibility to psychosis.

Topic Area: Ultra High Risk / Prodromal Research

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