The North American Prodrome Longitudinal Study: NAPLS 1, 2 and 3
Abstract: The North American Prodrome Longitudinal Study (NAPLS) consortium was initiated in 2003 with eight independently National Institute of Mental Health (NIMH) funded sites. Sites included the Universities of Yale, Calgary, North Carolina, Emory, Harvard, and the University of California at San Diego and at Los Angeles. In 2008, they were awarded a 5-year grant from NIMH to incorporate biological assessment approaches (neuroimaging, electrophysiological, hormonal and genetic) into a multi-site prospective study of 720 participants at clinical high risk for developing psychosis and 240 matched controls, known as NAPLS 2. Then in 2014 NAPLS was competitively renewed for a new 5-year study period (NAPLS 3) to further clarify the roles of neuroinflammation and deficient synaptic plasticity in the development of psychosis and a 9th site, the University of California, San Francisco was added. Numerous papers have been published from the NAPLS project, an overview of which will be the focus of this presentation.
University of Calgary – Canada
King’s College London – UK
Early intervention for bullying victimization
Abstract: Many people have childhood memories of being pushed around and being punched by other pupils when they felt they couldn’t respond. They may also remember being the topic of nasty rumours or being excluded by others. Unfortunately, being bullied is not an unusual experience even in the modern day. This presentation will emphasize 3 main points: 1) genetically-sensitive data are key to providing strong evidence that bullying victimization has an effect on mental health problems, and are not all due to genetic confounds; 2) longitudinal studies are crucial to test whether bullying victimization has an impact on mental health problems – and not just the other way around; 3) bullying victimization can be considered as targets for interventions aiming at both reducing risk factors associated with poor mental health and building the resources necessary to help face life’s challenges.
King’s College London – UK
Improving the long-term outcome of psychotic disorders through early intervention strategies
Abstract: Early intervention approaches attempt to improve the outcome of psychotic disorder through (1) improving the outcome of the initial critical period and (2) reducing the duration of untreated psychosis. These approaches have been adopted in many programmes around the world, providing specific services for patients presenting for the first time with a psychotic disorder. The actual programme design, resources and outcome vary in different programmes. This presentation focus on data from Hong Kong, a setting with a medium level of mental health resources. Longitudinal outcome data suggest that early intervention is effective in improving the long-term outcome of psychotic disorders. Besides, strategies for relapse prevention may also critically impact on the long-term outcome.
University of Hong Kong – Hong Kong
Preventing the onset of depressive disorders: Opportunities and challenges
Abstract: Depression is common, costly, has a strong impact on the lives of individuals and society and has a strong association with morbidity and mortality. Preventing the onset of depressive disorders is one of the main challenges for public health in the coming decades. In this presentation an overview of the research field will be given. Why prevention is important, whether preventive interventions are effective, examples of important trials in the field will be given, and possibilities to increase the impact on public health will be discussed.
University of Amsterdam – Netherlands
Intergenerational Psychiatry: A New Look at a Powerful Perspective
Abstract: The talk will start by discussing recent developments in our understanding of intergenerational processes in psychiatry, from animal studies to converging evidence among humans, expanded by new tools now available, such as neonatal brain imaging, and others (Duarte, Monk, Weissman & Posner, World Psychiatry, accepted). Specific mechanisms and the potential of an intergenerational approach for broadening our understanding of developmental processes in Psychiatry will be illustrated by ongoing studies of individuals growing up in disadvantaged contexts, particularly, the Boricua Youth Study and the Brazil Babies Study.
Cristiane S. Duarte
Columbia University – USA
Ludwig-Maximilian-University – Germany
Early Intervention: The Next Stage
University of Melbourne
Prevention and Early Intervention in Low and Middle-Income Countries: from Neuroscience to Public Health
Abstract: In this presentation, I will discuss strategies for health prevention, promotion, and treatment in low and middle-income countries. I will discuss original data on strategies from neuroscience and pragmatic implementation strategies in low resource settings.
Universidade Federal do Rio Grande do Sul – Brazil