Psychotic Experiences in childhood predict depressive disorder and any substance use in adolescence: findings from the Brazilian High Risk Cohort (HRC) study

Poster A24, Monday, October 8, 11:30 am - 1:00 pm, Essex Ballroom

Ary Gadelha1,2, Pedro M Pan1,2, Felipe Argolo1,2, Lais Fonseca1,2, Luisa von Nielander1,2, Rodrigo Bressan1,2; 1Universidade Federal de São Paulo (UNIFESP), 2Brazilian High Risk Cohort (HRC) study

PE predict common mental disorder and any substance use in youth. However, few studies investigate these associations in the transition from childhood to adolescence. We report on data from the Brazilian High Risk Cohort (HRC), a school-based sample from two Brazilian cities. We evaluated 2,244 subjects (6-12 years old) using the Community Assessment of Psychotic Experiences (CAPE) and an adapted version of the Comprehensive Assessment of At-risk Mental States (CAARMS) by self-report and clinician ratings, respectively, at baseline. At 3-year follow-up, we evaluated common mental disorders by the Development and Well-Being Assessment (DAWBA), by parent- and self-report. We grouped mental disorders into four DSM-based categories: any depressive disorder, any anxiety disorder, any Attention Deficit Hyperactivity Disorder (ADHD), and any Oppositional Defiant Disorder or Conduct Disorder (ODD/CD). We evaluated any substance use (any alcohol, tobacco, and drug use) by parent and self-report. We used logistic regression models to evaluate dimensional and categorical childhood PE as predictors of the four DSM-based categories of mental disorders and any substance use in adolescence. Categorical (OR 1.77;CI95%1.12-2.79) and dimensional (OR 2.47;CI95%1.53-6.05) PE increased the risk of any depressive disorder at follow-up, after controlling for baseline mental disorders. Categorical PE (OR 1.91;CI95%1.42-2.58) predicted any substance use by parent-report, while dimensional (OR 1.30;CI 95%0.92-1.84) PE did not. Dimensional PE (OR 1.91;CI95%1.42-2.58) was a significant predictor for any substance use by self-report, whereas categorical PE (OR 1.20;CI95%0.87-1.66) was not a significant predictor. Our results support previous findings that PE are non-specific markers for psychiatric vulnerability during neurodevelopment.

Topic Area: Diagnosis and Phenomenology

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