Poster A80, Monday, October 8, 11:30 am - 1:00 pm, Essex Ballroom

Varela Eva1, Puig Olga1,2, Baeza Inmaculada1,2,3, Sugranyes Gisela1,2,3, Badia Francina1, Forner Mireia1, Prades Nuria4, García-Rizo Clemente2,3,5, Anabel Martínez-Aran2,3,5, Granholm Eric6; 1Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic of Barcelona, 2017SGR881, Barcelona, Catalonia., 2Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain., 3CERCA-IDIBAPS, Barcelona, Catalonia, Spain., 4Department of Psychiatry and Psychology, Hospital Santa María of Lleida, Catalonia, Spain., 5Department of Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic of Barcelona., 6VA San Diego Healthcare System (VASDHS), San Diego, CA 92161, USA.

Traumatic experiences in childhood would cause dysregulations in the hypothalamic-pituitary-adrenal axis (HHAa) and alterations in cortisol levels1. OBJECTIVES: assess psychosocial adversity (AP) in adolescents with early onset psychosis (Adol_EOP); evaluate the relationship between AP and cortisol levels Adol_EOP. Methods: 15 Adol_EOP (11♀, age=15.33±1.23), 10 healthy controls (8♀, age=15.60±1.51), participating in CBSST trial in Hospital Clínic Barcelona. Inclusion criteria: EOP diagnosed between 9-18 years-old; within the 5 first years after the disease onset; clinical stability. Exclusion criteria: IQ<70; substance dependence disorder; neurological disorders. Instruments: CTQ scale (Childhood Trauma Questionnaire), determination of salivary cortisol at 08:00 a.m; BMI (Body mass index). Analysis: T-test, Chi-square test, Pearson correlation, partial correlation. Results. EOP and control groups were homogeneous in age (t=-0.49, p=0.632) and sex (X2=0.15, p=0.702) but not in SES, lower in patients (X2=10.69, p=0.030). PIP group had higher BMI (t=4.61, p=0.00) and higher scores in CTQ subscales of emotional abuse (t=15.80, p=0.01), physical negligence (t=8.50, p=0.007) and in their severity (t=16.73, p=0.00; t=5.62, p=0.026). Levels of salivary cortisol correlated positively with AP: emotional abuse (r=0.52, p=0.30), physical abuse (r=0.78, p=0.00) and severity (r=660, p=0.004), sexual abuse (r=0.926, p=0.00) and severity (r=0.650, p=0.005), physical negligence (r=0.616, p=0.008) and severity (r=714, p=0.001). These results were maintained controlling by SES and BMI. Conclusions. Adol_EOP had higher and more severe AP, which was associated with current higher levels of cortisol, supporting a dysregulation of the HHAa. Acknowledgments:FAK. 1. Lange C et al. Modulation of HPA axis response to social stress in schizophrenia by childhood trauma. Psychoneuroendocrinology. 2017

Topic Area: First Episode Psychosis

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