Childhood medical history and risk of psychosis: a retrospective case-control study

Poster A100, Monday, October 8, 11:30 am - 1:00 pm, Essex Ballroom

Ilaria Tarricone1, Elena Tolomelli1, Federico Suprani1, Monia Gennari1, Marcello Lanari1, Domenico Berardi1; 1University of Bologna

Childhood adversity is a widely replicated risk factor for psychosis; however, few studies have specifically investigated if pediatric hospitalizations or emergency room (ER) accesses could represent risk factors for psychosis as well. The aim of this retrospective case-control study was to determine if a history of hospitalizations or ER admissions during childhood could increase the risk of psychosis onset in adult life. 168 patients with first-episode psychosis (FEP) and 85 healthy controls were included. Available digital records of hospitalizations and ER admissions were retrospectively retrieved. We found that Individuals who were hospitalized (OR= 3.213; 95% CI = 1.027 – 10.052) or admitted into ER (OR = 8.823; 95% CI = 2.491 – 31.245) were more likely to develop psychosis. Moreover the risk of psychotic onset increased as the number of hospitalizations (OR = 2.399; 95% CI = 1.076 – 5.347) or ER admissions (OR = 3.573; 95% CI = 1.590 – 8.030) grew. According to these results, it might be possible to consider children who access ER or who are hospitalized more than once at high-risk of developing psychosis in adult life.

Topic Area: First Episode Psychosis

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