Reduced Fronto-Temporal Cortical Gyrification associated with Psychotic Like Experiences in healthy adolescents
Poster B48, Tuesday, October%209, 11:30%20am%20-%201:00%20pm, Essex%20Ballroom
Raka Maitra1, Evangelos Papanastasiou1, Christian Gaser2, Tobias Banaschewski3, Gareth J Barker4, Arun L.W. Bokde5, Uli Bromberg6, Christian Büchel6, Erin Burke Quinlan7, Sylvane Desrivières7, Herta Flor8,9, Vincent Frouin10, Hugh Garavan11, Penny Gowland12, Andreas Heinz13, Bernd Itterman14, Jean-Luc Martinot15, DimitriPapadopoulos Orfanos10, Alex Ing7, IMAGEN Consortium, Gunter Schumann7, Sukhi Shergill1; 1Department of Psychosis studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, 2Department of Neurology, Jena University Hospital, Jena, Germany, 3Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 4Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, 5Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland, 6University Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martinistr. 52, 20246, Hamburg, Germany, 7Centre for Population Neuroscience and Stratified Medicine (PONS) and MRC-SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, 8Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 9Department of Psychology, School of Social Sciences, University of Mannheim, 68131 Mannheim, Germany, 10NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France, 11Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, Vermont, USA, 12Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom, 13Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany, 14Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany [or depending on journal requirements can be: Physikalisch-Technische Bundesanstalt (PTB), Abbestr. 2 – 12, Berlin, Germany, 15Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry”, University Paris Sud – University Paris Saclay, DIGITEO Labs, Gif sur Yvette, France
Psychotic Like Experiences, PLEs, are prevalent in general population and increase the risk of developing psychosis. Cortical gyrification, a stable marker for neurodevelopmental abnormalities, may contribute to PLEs. CAPE-42 is a valid and reliable self-report questionnaire for PLEs in healthy adults and adolescents. We used the MRI data of 600 adolescents already acquired by the IMAGEN study. We compared cortical gyrification of 313 adolescents with high CAPE scores with 287 adolescents with low CAPE scores, at baseline (age 14yrs) and at follow up (age 16-19yrs). At both baseline and follow up, high CAPE scorers had reduced gyrification in the left superior frontal gyrus, the left middle temporal gyrus, and the area around left superior temporal sulcus. At baseline, high CAPE scorers had reduced gyrification in the right temporal pole, which was normalised at follow up, perhaps indicating an ongoing brain maturation process in adolescents. The left superior frontal gyrus is associated with self-awareness, while the left superior temporal sulcus is associated with voice perception and theory of mind and the left middle temporal gyrus plays an important role in language processing and semantic cognition. In line with the continuum theory of psychosis, persistent PLEs are prodromal psychotic manifestations. Our results show that persistent neurodevelopmental abnormalities such as reduced gyrification in the left fronto-temporal region comprising of the superior frontal gyrus, the superior temporal sulcus and the middle temporal gyrus underlie PLEs in healthy adolescents.
Topic Area: Neuroimaging