Interventions and Social Functioning in Youth at Risk of Psychosis: A Systematic Review and Meta-Analysis
Poster B71, Tuesday, October%209, 11:30%20am%20-%201:00%20pm, Essex%20Ballroom
Daniel Devoe1, Megan S Farris1, Parker Townes1, Jean Addington1; 1University of Calgary
Aim: Youth at clinical high risk (CHR) for psychosis often exhibit difficulties in social functioning and poorer social functioning may be predictive of transition to a psychotic disorder. Therefore, the primary objective of this systematic review was to summarize the impact of all interventions on social functioning in CHR samples. Method: Electronic databases PsycINFO, CINAHL, Embase, EBM, and MEDLINE were searched from 1951 to June 2017. Studies were selected if they included any intervention that reported changes in social functioning in youth at CHR. Data was evaluated using random effects pairwise meta-analyses, stratified by time, and reported as the standardized mean difference (SMD). Results: Nineteen studies met our inclusion criteria, including a total of 1,667 CHR participants. The mean age was 20.5 years and 47% were male. Cognitive behavioural therapy (4 studies) did not significantly improve social functioning at 6-months (SMD=0.06; 95% CI=-0.35, 0.46), 12-months (SMD=-0.15; 95%CI= -0.41, 0.11), and 18-months (SMD=0.20; 95%CI=-0.10, 0.50). Omega-3 (2 studies) did not significantly improve social functioning at 6-months (SMD=0.01; 95CI=-0.21, 0.24) and 12-months (SMD=-0.08; 95%CI= -0.33, 0.17). Lastly, cognitive remediation (3 studies) did not significantly improve social functioning at 2-3-month follow-up (SMD=-0.18, 95%CI=-0.91, 0.56). Conclusions: This systematic review and meta-analysis demonstrated that no treatment significantly improved social functioning in youth at CHR. Future randomized control trials are required that are designed to target and improve social functioning in youth at CHR for psychosis.
Topic Area: Ultra High Risk / Prodromal Research