Functional and Structural Correlates of Abnormal Involuntary Movements in Psychosis Risk, First Episode Psychosis and Clinical Controls
Poster B88, Tuesday, October%209, 11:30%20am%20-%201:00%20pm, Essex%20Ballroom
Jochen Kindler1, Chantal Michel, Frauke Schultze-Lutter, Alexandra Martz-Irngartinger, Benno G Schimmelmann, Michael Kaess, Daniela Hubl, Sebastian Walther; 1University Hospital of Child and Adolescent Psychiatry and Psychotherapie, Bern, Switzerland
Increased abnormal involuntary movements (AIM) have previously been described in patients with clinical high risk for psychosis (CHR). However, knowledge on the pathophysiology of increased AIM in CHR remains sparse. Here, we evaluated the prevalence of AIM in patients with CHR, first episode psychosis (FEP) and clinical controls (CC). Furthermore, we tested the association of AIM with regional cerebral blood flow (rCBF) and gray matter volume (GMV). Videos on patients with CHR, FEP and CC were evaluated by two independent and blinded raters, using the abnormal involuntary movement scale. Additionally, arterial spin labeling MRIs and structural MRIs were measured to investigate the association of AIM with rCBF and GMV. Significantly higher AIM scores were detected in CHR and FEP as compared to CC. Furthermore, AIM scores correlated positively with rCBF in the premotor cortex, Brodmann area 6, and negatively with GMV of the corresponding caudal middle frontal gyrus. This is the first video-based analysis to report increased AIM in CHR and FEP patients as compared to CC. The results of the MR analysis indicate higher neuronal activity as measured by rCBF and decreased GMV in the premotor cortex, which is responsible for planning, initializing and suppressing of motor functions, in AIM.
Topic Area: Ultra High Risk / Prodromal Research