The relationships between childhood trauma and cognitive biases, cognitive functions and symptoms among individuals prone to psychosis.

Poster B32, Tuesday, October 9, 11:30 am - 1:00 pm, Essex Ballroom

Łukasz Gawęda1, Martyna Krężołek1, Renata Pionke2, Aneta Kalisz3, Piotr Błądziński3, Andrzej Cechnicki3, Błażej Misiak4, Kamila Kotowicz5, Barnaby Nelson6, Dorota Frydecka5; 1II Department of Psychiatry, The Medical University of Warsaw, 2Institute of Psychology, Polish Academy of Sciences, Warsaw, Poland., 3Department of Community Psychiatry, Chair of Psychiatry, Medical College, Jagiellonian University, Krakow, Poland., 4Department of Geneticts, Wroclaw Medical University, Poland., 5Department of Psychiatry, Wroclaw Medical University, Poland., 6Orygen, The National Centre of Excellence in Youth Mental Health, The University of Melbourne, Australia; Centre for Youth Mental Health, The University of Melbourne, Australia.

The relationship between childhood trauma and a risk for developing psychosis is well established. Little is known however about cognitive correlates of trauma which may foster our understanding of the mechanisms how life adversity shape psychosis vulnerability. The aim of our study was to investigate relationships between childhood trauma and cognitive biases, cognitive functions and symptoms. A total of 54 (25 females; mean age 25.63, SD= 4.80) individuals from general population (n=3006) with the highest score in Prodromal Questionnaire (PQ-19) were clinical assessed using the Comprehensive Assessment of At-Risk Mental States (CAARMS). Cognitive biases were assessed with self-report scale – DACOBS, as well as two experimental tasks assessing jumping to conclusions (the Fish Task) and source monitoring (Action Memory Task). Cognitive functions were assessed by Brief Cognitive Assessment Tool for Schizophrenia (B-CATS), California Verbal Learning Test (CVLT) and D2 Test of Attention. Childhood trauma was measured by The Childhood Experience of Care and Abuse Questionnaire (CECA.Q). All type of trauma was significantly related with cognitive biases, neurocognitive functioning and symptoms. Emotional abuse was related with source monitoring error (r=0,36, p<0.01), verbal learning (r=0.34, p<0.05) and mood lability (r=0.33, p<0.05). The physical abuse showed a significant relation with external attribution bias (r=0.35, p<0.01), attention (r=0,39, p<0.01) and positive symptoms (r=0.36, p<0.05). The sexual abuse turned out to be related with jumping to conclusion task 80:20 (r=0.33, p<0.05) and suicidality (r=0.39, p<0.01). Dysfunctional information processing as well as compromised neurocognitive functioning is related to early childhood trauma and may shape vulnerability to psychosis.

Topic Area: Neurocognition

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