Negative Symptoms in Youth At Clinical High Risk for Psychosis: A Systematic Review and Meta-Analysis

Poster B73, Tuesday, October 9, 11:30 am - 1:00 pm, Essex Ballroom

Daniel Devoe1, Jean Addington1; 1University of Calgary

Evidence suggests that understanding negative symptoms in those at clinical high risk (CHR) for psychosis may elucidate important pathophysiological mechanisms in schizophrenia. Thus, we conducted a systematic review and meta-analysis of negative symptom studies in youth at CHR for psychosis. We searched CINAHL, EBM, PsycINFO, Medline, Embase from inception. Studies were selected if they demonstrated a relationship between negative symptoms and another variable (e.g. transition to psychosis) in a sample of CHR participants. Treatment studies were excluded. Due to the differences in negative symptom scales effect sizes were reported as the standardized mean difference (SMD) and analyzed with random effects meta-analyses. Of 3,043 citations, 103 studies met our inclusion criteria, including a total of 12,168 CHR participants. The mean age was 19.44 years (SD=8.92) and 6,927 (56.9%) were female. We identified 13 unique associations including functioning (n=31), transition (n=23), symptoms (n=12), cognition (n=11), brain regions (n=8), gender (n=8), cannabis use (n=5), ethnicity (n=3), postural sway (n=3), family relationships (n=3), biological interactions (n=3), and P300 amplitude (n=3). In the pairwise meta-analysis, negative symptoms were significantly higher at baseline in those who transitioned to psychosis compared to those who did not transition (SMD= 0.68; 95% CI, 0.44 to 0.91; I2= 0%; P<0.00001, 7 studies). This review demonstrated a significantly large effect size between baseline negative symptoms in those who transitioned to psychosis compared to those who did not transition. Additionally, this review identified a large body literature that describes the relationship between negative sympt

Topic Area: Ultra High Risk / Prodromal Research

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