Paliperidone palmitate: continuation rates and patterns of discontinuation depending on the starting place of treatment
Poster A103, Monday, October 8, 11:30 am - 1:00 pm, Essex Ballroom
Sergio Sanchez-Alonso1, Nora Palomar1, Marina LLaguno1, Santiago Ovejero1, Marta Migoya1, Alba Sedano1, Fanny Cegla1, Silvia Vallejo1, Raquel Álvarez2, Adrián López1, Manuel Vásquez1, Laura Mata1; 1Departamento de Psiquiatría. Hospital Universitario Fundación Jiménez Díaz. Madrid, 2Departamento de Psiquiatría. Hospital Universitario Rey Juan Carlos. Móstoles
Objectives: The aim of this study is to describe the continuation rates after one and two and years follow-up in patients treated with paliperidone palmitate depending on the starting place of treatment. Methods: This is a non-interventional study, in a naturalistic framework for a period of 2 years. It is a sample of 172 patients who started treatment with paliperidone palmitate. Maintenance rates were compared at one year and two years follow-up depending on the starting place of treatment. Results: 92.6% of outpatient patients maintained the treatment at one year follow-up compared with 86% as inpatient beggining. No statistical differences (Log Rank (Mantel-Cox): 0.20). No statistically significant differences were found in the reasons for withdrawal. The mean number of days until withdrawal is greater in the outpatient setting (202.78 Vs 115.14), but no statistical differences were demonstrated. Continuation rates at 2 years follow-up are 88.6% in outpatient beginnig and 73.2% as inpatient. There were no statistical differences (Log Rank (Mantel-Cox): 0.21). No statistically significant differences were found in the reasons for withdrawal. The mean number of days until withdrawal is greater in the outpatient setting. No statistical differences were demonstrated. Conclusions: The use of paliperidone palmitate allows higher continuation rates than those reflected in the literature2 and allows high retention rates in both an inpatient and outpatient settings. Retention rates in patients who started treatment in an outpatient setting are greater than those observed in patients who initiate treatment in an inpatient setting2. However, no statistically significant differences were observed.
Topic Area: Psychopharmacology