Effects of Aerobic Interval Training among overweight individuals with psychosis and factors associated with physical activity persistence- preliminary results

Poster A138, Thursday, October 20, 11:30 am - 1:00 pm, Le Baron

Ahmed Jerome Romain1, Cedine Fankam1, Antony Karelis2, Gladys Mikolajacks1, Elaine Letendre3, Emmanuel Stip1,3,4, Amal Abdel-Baki1,3,4; 1University of Montreal Hospital Research Centre, Montreal, QC, Canada, 2University of Quebec at Montreal, Montreal, QC, Canada, 3University Hospital of Montreal, Montreal, QC, Canada, 4University of Montreal

Purpose. To measure the feasibility and effects of a 6-month interval training (IT) program on metabolic, anthropometric, psychiatric/functional outcomes and analyze what predict physical activity (PA) persistence. Methods: Randomized controlled trial comparing the effects of a bi-weekly 30 minutes supervised IT to a waiting list in overweight individuals with psychosis and questionnaires evaluating motivation to exercise with the transtheoretical model (TTM). Results: On the targeted sample of 66 individuals, 48 participants with psychosis (27 men, mean age: 31.42±7.41; mean BMI: 32.32±5.68 kg/m²) of which 24 were first-episode psychosis (FEP), already completed the study. Effects of IT were significant on waist circumference (-3.08 cm, SE = 1.46; p = 0.04), diastolic blood pressure (-5.91 mmHg, SE = 2.87; p = 0.04), HDL cholesterol (0.14 g/l, SE = 0.06; p = 0.03), and social functioning (SOFAS) (5.84, SE = 2.33; p = 0.01), with a trend on apoliprotein B (0.11 mg/dl, SE = 0.06; p = 0.07). Effects of exercise in the FEP sub-group were similar to those of the entire cohort. Persistence to PA was associated to higher use of TTM behavioral processes of change (p = 0.003) and a higher perception of advantages to exercise (p = 0.001). Conclusion: These preliminary analyses show promising results suggesting that IT can be used successfully in the management of metabolic complications and possibly improve social functioning in FEP. The TTM seems an interesting theoretical framework to understand PA persistence which could help designing PA interventions.

Topic Area: Translational Research

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