Predictive capacity of prodromal symptoms in first-episode psychosis of recent onset

Poster A58, Thursday, October 20, 11:30 am - 1:00 pm, Le Baron

Ana Barajas1,2,3,4,5, Trinidad Peláez2, Olga González2, Judith Usall2, Raquel Iniesta4, Maria Arteaga2, Chris Jackson6, Iris Baños4, Bernardo Sánchez3, Montserrat Dolz3, GENIPE Group7, Susana Ochoa2; 1Department of Research, Centre d’Higiene Mental Les Corts, Barcelona, Spain. PhD, 2Parc Sanitari Sant Joan de Déu, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Sant Boi de Llobregat, Barcelona, Spain., 3Hospital Sant Joan de Déu de Barcelona, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Esplugues de Llobregat, Barcelona, Spain, 4Fundació Sant Joan de Déu de Barcelona, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Esplugues de Llobregat, Barcelona, Spain, 5Departament de Psicologia Clínica i de la Salut, Facultat de Psicologia, Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Spain., 6Birmingham Early Intervention Service, Birmingham and Solihull Mental Health Foundation Trust, Birmingham, UK, 7GENIPE group is a multidisciplinary group of researchers: Araya S, Arranz B, Arteaga M, Asensio R, Autonell J, Baños I, Bañuelos M, Barajas A, Barceló M, Blanc M, Borrás M, Busquets E, Carlson J, Carral V, Castro M, Corbacho C, Coromina M, Dachs I, De Miquel L, Dolz M, Domenech MD, Elias M, Espezel I, Falo E, Fargas A, Foix A, Fusté M, Godrid M, Gómez D, González O, Granell L, Gumà L, Haro JM, Herrera S, Huerta E, Lacasa F, Mas N, Martí L, Martínez R, Matalí J, Miñambres A, Muñoz D, Muñoz V, Nogueroles R, Ochoa S, Ortiz J, Pardo M, Planella M, Pelaez T, Peruzzi S, Rivero S, Rodriguez MJ, Rubio E, Sammut S, Sánchez M, Sánchez B, Serrano E, Solís C, Stephanotto C, Tabuenca P, Teba S, Torres A, Urbano D, Usall J, Vilaplana M, Villalta V

BACKGROUND: Both the nature and number of a wide range of prodromal symptoms have been related to the severity and type of psychopathology in the psychotic phase. However, at present there is an incomplete picture focused mainly on the positive pre-psychotic dimension. AIMS: To characterize the prodromal phase retrospectively, analyzing the number and nature of prodromal symptoms as well as their relationship with psychopathology at the onset of first-episode psychosis. METHOD: Retrospective study of 79 patients experiencing a first-episode psychosis of less than one year from the onset of full-blown psychosis. All patients were evaluated with a comprehensive battery of instruments including socio-demographic and clinical questionnaire, IRAOS interview, PANSS, stressful life events scale (PERI), and WAIS/WISC (vocabulary subtest). Bivariate associations and multiple regression analysis were performed. RESULTS: Regression models revealed that several prodromal dimensions of IRAOS (Delusions; Affect; Language; Behavior; Non-hallucinatory disturbances of perception) predicted the onset of psychosis, with positive (22.4% of the variance) and disorganized (25.6% of the variance) domains being the most widely explained. CONCLUSION: In addition to attenuated positive symptoms, other symptoms as affective, behavioural, and language disturbances, should also be considered in the definitions criteria of at-high-risk people.

Topic Area: First Episode Psychosis

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