Differences in prolactin serum levels between genetic variants of the ANKK1 gene in incipient psychosis

Poster A121, Thursday, October 20, 11:30 am - 1:00 pm, Le Baron

Vanessa Sanchez-Gistau1, Montse Sole1, Angel Cabezas1, Sara Arranz1, M Jose Algora1, Lorena Moreno1, Xavier Labad2, Elisabet Vilella1; 1Early intervention service of psychosis. Hospital Universitari , Institut Pere Mata, Reus. CIBERSAM, 2Department of psychiatry , Hospital Parc Tauli, sabadell . CIBERSAM

Background. The rs1800497 (SNP) (T/C) polymorphism of the ANKK1 gene , likely modulates the function and expression of DRD2 due to its close proximity. Hyperprolactinemia is a common side effect induced by antipsychotic agents through dopamine D2 receptor antagonism AIMS: To determine whether prolactin serum level differs between rs1800497 T (minor allele) and C carriers. Methods: 112 subjects (76 presenting their first-episode of psychosis in the last two years and 36 at risk mental state (ARMS) assessed by CAARMS) were recruited from the outpatient Early Intervention Psychosis Service in Reus, Spain. Differences in prolactin serum levels , positive and negative symptoms measured by PANSS and antipsychotic dose ( equivalent chlorpromazine dose) between TT and TC/CC carriers were analyzed using U-Mann-Whitney tests. Multivariate analysis of covariance (MANCOVA) was performed to determine the effects in prolactin levels of rs1800497 genotypes controlling for gender and antipsychotic treatment. RESULTS Frequencies of SNP rs1800497 variants were TT 11.6%, TC 22.3% and CC 66.1%: Homozygote T carriers presented higher prolactin levels( z=-.2.01; p=04), higher antipsychotic chlorpromazine equivalent dose( z=--2.34; p=02 and more negative symptoms(z=-2.06 ; p=04) than TC -CC carriers . When correcting for gender and antipsychotic dose in multivariate analysis, associations between higher prolactin T carriers remained significant Conclusions: Our results suggest that TT ANK 1 carriers may present a vulnerability group to suffer dopamine related adverse events such as hyperprolactinemia than CC-CT carriers. Given the low frequency of homozygote TT carriers, further studies in larger samples are warranted

Topic Area: Genetics

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