Self-Rated Experience of Disability in First-Episode Psychosis at 1 year Follow-up and its Relationship to Psychosis and Depression

Poster A108, Thursday, October 20, 11:30 am - 1:00 pm, Le Baron

Carmen Simonsen1, Ann Faerden1, Kristin Lie Romm1,2, Torill Ueland1,2, Anja Vaskinn1,2, Thomas Bjella1,2, Ole Andreassen1,2, Ingrid Melle1,2; 1Oslo University Hospital, 2University of Oslo

Purpose Self-rated experience of disability in first episode psychosis (FEP) at 1 year follow-up was investigated. How it relates to clinician-rated functioning as well as psychosis and depression was addressed. Methods FEP participants (n=91) in the TOP study were investigated at baseline and 1 year follow-up. Self-rated Experience of Disability was measured with World Health Organization Disability Assessment Schedule 2.0 (WHODAS) including 6 domains. Clinician-rated global functioning was measured with Global Assessment of Functioning Scale-Split version (GAF-F). Psychotic symptoms were measured with Positive and Negative Syndrome Scale (PANSS), with symptomatic remission defined according to the internationally standardised criteria. Depression was measured with Calgory Depression Scale for Schizophrenia (CDSS), with a score above 5 defined as clinically significant depression. Results Self-rated experience of disability was highest in the 3 social domains: understanding and communication, getting along with others and participation in society, all which correlate with clinician-rated functioning. Self-rated disability was more strongly correlated with depression than psychosis. Depression was less common in the symptomatic remission group (8%) than in the non-remission group (49%). Self-rated disability was significantly higher in the non-remission compared to the remission group on all domains, yet the difference was greater between participants with and without depression. Conclusion Subjective experience of disability was highest within social domains, and improves with symptomatic remission, but even more so with alleviation from depression. This highlights the importance of treating depression as well as psychosis in order to improve social functioning in the early phases of psychosis.

Topic Area: First Episode Psychosis

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