The predictive value of negative symptoms for transition and functioning in individuals at ultra high risk of psychosis: a meta-analysis

Poster C114, Saturday, October 22, 11:30 am - 1:00 pm, Le Baron

Aaltsje Malda1, Nynke Boonstra2, André Aleman3, Mark van der Gaag4, Marieke Pijnenborg5; 1GGZ Friesland, Department Early Detection and First Episode Psychosis, Leeuwarden; Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, The Netherlands, 2GGZ Friesland,Department Early Detection and First Episode Psychosis, Leeuwarden; NHL University of applied sciences Leeuwarden, The Netherlands, 3University Medical Center Groningen, University of Groningen, Neuroimaging Center Groningen, The Netherlands, 4Department of Clinical Psychology, VU University and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands; Department of Public Mental Health, Trimbos Institute (Netherlands Institute of Mental Health and Addiction), Utrecht, The Netherlands; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands, 5Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, Groningen, the Netherlands. Department of Psychotic Disorders, GGZ Drenthe, Assen, the Netherlands

Introduction: The Ultra High Risk criteria are most widely applied criteria to determine whether an individual has an elevated risk of becoming psychotic. However, the majority of individuals with UHR does not convert and the high rate of false positives has lead to a growing interest in finding additional predictors for transition to a psychosis. A potential predictor are in UHR highly prevalent negative symptoms. Social functioning is another important outcome: studies reported lower functioning in individuals with UHR, irrespective of conversion. Unknown is whether longitudinal functioning in UHR is predicted by negative symptoms at baseline. Aims: to examine 1) whether negative symptoms at baseline are a significant predictor of transition to psychosis, 2) whether negative symptoms predict functioning at follow-up, irrespective of occurrence of transition. Methods: A systematic 2-step search strategy with electronic and manual search was preformed independently by two reviewers. Inclusion criteria: (1) reported in a peer-reviewed journal, (2) UHR subjects defined according to established international criteria, (3) negative symptoms assessed with standardized measurements, (4) functioning measured at follow-up. 2176 titles and 307 abstracts were screened; the results from 30 studies will be presented. Results: 1) a majority of studies report that individuals with UHR with a transition to psychosis report a significant higher amount of negative symptoms at baseline. 2) negative symptoms are significantly associated with lower social functioning in individuals at UHR. Conclusion: Negative symptoms are an additional predictor in UHR in predicting subsequent psychotic disorder and functioning and therefore should be targeted in treatment.

Topic Area: Ultra High Risk / Prodromal Research

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