Electroretinographic and cognitive risk endophenotypes predicts risk of major mood and psychotic disorders in children born to an affected parent

Poster B41, Friday, October 21, 11:30 am - 1:00 pm, Le Baron

Elsa Gilbert1,2, Thomas Paccalet2,3, Valérie Jomphe2, Nathalie Gingras2,4, Marc Hébert2,4, Anne-Marie Gagné2, Chantal Mérette2,4, Michel Maziade2,4; 1Université Laval, École de Psychologie, 2Centre de recherche, Institut universitaire en santé mentale de Quebec, CIUSSS de la Capitale Nationale, 3Université du Québec à Trois-Rivières, 4Université Laval, Faculté de Médecine

Background: Risk endophenotypes (cognitive or electrophysiological) observed in adult patients are found in children born to a parent affected by affective and non-affective major psychoses (MP). Such endophenotypes are usually investigated separately. Our objectives were in at-risk children-adolescents: i) to investigate the accumulation of cognitive deficits and electroretinographic (ERG) anomalies; ii) to study the relationship between these endophenotypes. Methods: From a 25-year follow-up of 48 kindreds densely affected by MP starting with 1500 adults (405 were affected by MP), we longitudinally collected extensive measures of cognitive domains and ERG in high-risk offspring (HR, aged 6 to 26 yrs, n=84), compared to 189 controls matched for age and gender. Participants were administered neuropsychological, ERG and clinical assessments. Results: Single deficits in verbal and visual episodic memory, working memory, processing speed or executive functions and single ERG anomalies were more frequent in HR than in controls (odds ratio OR2.8 for cognition and 3.0 for ERG). Rates of combinations of endophenotypes were greater among HR with an OR of 4.7 for cognition and 4.8 for ERG. Our 11-year follow-up allowed us to preliminarily observe that HR who transitioned to MP had more accumulation of risk endophenotypes than those who remained healthy. Discussion: Cognitive and ERG endophenotypes accumulate in a child independently of each other and would characterize the HR who later transition to a MP. These findings are compatible with the multi-trait polygenic theory of psychosis. Investigating the combinations of risk endophenotypes might help for modeling the preclinical staging of children-adolescents at risk.

Topic Area: Neurodevelopmental

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