Who benefits from prolonged early intervention? – Further investigations into sub-groups of the OPUS II study

Poster A125, Thursday, October 20, 11:30 am - 1:00 pm, Le Baron

Nikolai Albert1,2, Carsten Hjorthøj1,2, Marianne Melau1, Heidi Jensen1, Merete Nordentoft1,2; 1Mental Health Centre Copenhagen, Copenhagen University Hospital, 2Copenhagen University

Purpose: This study is sub-group analysis a larger randomized trial testing prolonged early intervention for patients diagnosed with a first episode schizophrenia spectrum disorder (The OPUS II study). The current study aims to investigate if there are certain sub-groups within the study who benefits more from the treatment. Earlier studies have shown that the most sever patients benefit the most from early intervention programs. Materials and Methods: The OPUS II study recruited 400 patients who were 1 ½ year into their OPUS treatment program. Standard OPUS treatment lasts for 2 years which after patients are transferred to community health centers. Half of the recruited patients were randomized to continuing OPUS treatment for altogether 5 years. Based on the baseline values patients were stratified on psychopathology into four groups, those in remission of both positive and negative symptoms, those only in remission on one domain and those not in remissions on any of the domains. These groups were then re-analyzed for treatment effect of the prolonged treatment. Results: Early analysis does not find that the prolonged treatment has any effect on any of the psychopathological domains for any of the four sub-groups, but results for all social and functional outcomes will be ready for the IEPA conference. Discussion: Implications of results and areas of interest for further studies will be discussed.

Topic Area: Psychosocial Interventions

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