Social cognition in patients at ultra-high risk for psychosis. What is the relation to social skills and functioning?

Poster B28, Friday, October 21, 11:30 am - 1:00 pm, Le Baron

Louise Birkedal Glenthøj1,2, Birgitte Fagerlund2,3, Carsten Hjorthøj1, Jens Richardt M Jepsen2,3,4, Nikolaj Bak2,3, Tina D Kristensen1,2, Christina Wenneberg1,2,5, Kristine Krakauer1,2,5, David L Roberts6, Merete Nordentoft1,2; 1Mental Health Centre Copenhagen, University of Copenhagen, 2Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, 3Centre for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, Copenhagen University Hospital, 4Child and Adolescent Mental Health Centre, Mental Health Services Capital Region of Denmark, University of Copenhagen, 5Functional Imaging Unit, Department of Diagnostics, 6Department of Psychiatry, Division of Schizophrenia and Related Disorders, University of Texas Health Science Center, San Antonio

Objective: Patients at ultra-high risk (UHR) for psychosis show significant impairments in functioning. It is essential to determine which factors influence functioning, as it may have implications for intervention strategies. This study examined whether social cognitive abilities and clinical symptoms are associated with functioning and social skills. Methods: The study included 65 UHR patients and 30 healthy controls. Social cognitive function, social skills, and a broad range of functioning measures were assessed. Results: The UHR patients demonstrated significant decrements on the Awareness of Social Inferences Task total score (p=.046, d=.51), and on the CANTAB emotion recognition task total percent correct (p=.023, d=.54) displaying particular difficulties in negative affect recognition. The patients exhibited significant impairments in social skills measured with the High Risk Social Challenge (p˂.001, d=1.05). Aspects of emotion recognition were associated with role functioning and social skill performance. The level of attributional bias was associated with overall functioning, and theory of mind ability was associated with self-reported functioning. Negative symptoms were associated with all measures of functioning(p ≤.05). Conclusion: Significant impairments in social cognition and social skills were found in UHR patients. The patients’ social cognitive function was associated with overall functioning and social skills. Negative symptoms appear to play an important role for functioning. Research is needed to investigate how the relations between social cognition, social skills and functioning develop from the UHR state to the stage of manifest illness. Research into how deficits in social cognition and social skills can be ameliorated in UHR patients is warranted.

Topic Area: Neurocognition

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