Early traumas in young adults with Familial and Clinical Risk for Psychosis in the Oulu Brain and Mind study - a Follow-up of the Northern Finland Birth Cohort 1986

Pirjo Helena Mäki1,2,3,4, Tuija Mähönen1, Tanja Nordström5, Juha M Veijola1,2,3; 1Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Finland, 2Department of Psychiatry, Oulu University Hospital, Finland, 3Medical Research Center, University of Oulu and Oulu University Hospital, Finland, 4Länsi-Pohja Healthcare District, Department of Psychiatry, Keropudas; the Middle Ostrobothnia Central Hospital, Department of Psychiatry, Kiuru; Joint Municipal Authority of Wellbeing in Raahe District, Mental Health Services; Basic Health Care District of Kallio, Mental Health Services and the Northern Ostrobothnia Hospital District, Visala Hospital, Finland, 5Center for Life Course Epidemiology, University of Oulu, Finland

Purpose: According to literature, childhood trauma increases the risk for psychosis and prodromal symptoms, too. However, early trauma in subjects with Familial Risk for psychosis is less studied. Objective was to study childhood traumas in young adults with parental psychosis. Aim was also to study association between childhood traumas and prodromal symptoms and psychosis in a birth cohort sample. Materials and Methods: A field study for a subsample of the general population based Northern Finland 1986 Birth Cohort was conducted in 2007-2010. According to the Structured Interview for Prodromal Syndromes SIPS and the Care Register for Health Care and other register data four groups were created: Familial Risk FR (N = 61), Clinical Risk CR (N = 47) for psychosis, Psychosis (N = 30) and Controls (N = 74). The Trauma and Distress Scale (TADS) – questionnaire was used to measure five types of traumatic childhood and adolescence experiences: emotional, physical and sexual abuse and emotional and physical neglect. Results: Subjects with FR did not have increased risk for any of the trauma types compared to controls after adjusting with gender, family type and socio-economic status. Participants with CR had increased risk for emotional abuse (p<0.01), physical abuse (p<0.05) and emotional neglect (p<0.01) compared to controls. Subjects with Psychosis had increased risk having had experienced emotional (p<0.05), physical (p<0.05) and sexual abuse (p<0.01) compared to controls. Conclusions: Surprisingly, parental psychosis did not increase the risk for early traumatic experiences. As expected, early traumas were connected to psychoses and prodromal syndromes.

Topic Area: Epidemiology

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